CU-CPT17e (C09-1120-824)

CU-CPT17e is a potent multi- Toll-like receptor ( TLR ) agonist that activates TLR3 , TLR8 , and TLR9 .In VitroCU-CPT17e shows strong NF-κB activation in TLR3, TLR8 and TLR9 HEK293 cells with EC 50 values of 4.80±0.73, 13.5±0.58 and 5.66±0.17 μM, respectively. CU-CPT17e significantly improves the activity with 13.9±0.9 fold of NF-κB activation and an EC 50 value of 4.8±0.7 μM. CU-CPT17e inhibits the proliferation of HeLa cancer cells by triggering apoptosis and arresting the cell cycle at the S phase. The induction of apoptosis by CU-CPT17e in HeLa cells is investigated. HeLa cells are cultured with increasing concentrations of CU-CPT17e or poly I:C or blank control (DMSO) for 24 h. Treatment with CU-CPT17e for 24 h at different concentrations (10 to 40 μM) results in an elevation of apoptotic cell population ranging from 10% to 17%, which is more effective than poly I:C at 5 μg/mL. These results suggest that the antiproliferative activity of CU-CPT17e against HeLa cells might result from its ability to directly induce apoptosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:TLR3 TLR8 TLR9. Specifications and Purity: ≥98.0%. Molecular Formula: C27H24N2O8. Molecular Weight: 504.49. PubChem CID: 132585194. Isomeric SMILES: C1COCCC12C=CC3=CC(=C(C=C3O2)OCC4=CC=C(C=C4)[N+](=O)[O-])OCC5=CC=C(C=C5)[N+](=O)[O-].