Biochem/physiol Actions
CuATSP is a CuATSM analog with >10-fold enhanced ferropotosis inhibitory potency (CuATSP/CuATSM IC50 against 150 nM RSL3-induced ferroptosis = 8.5/160 nM using Pfa1 mouse embryonic fibroblasts,16/170 nM using HT-22 mouse hippocampal cells). CuATSP and CuATSM exert their radical-trapping antioxidant (RTA) and (phospho)lipid peroxidation inhibitory potency via an initial reversible addition of a peroxyl radical to the bis(thiosemicarbazone) ligand, followed by a subsequent H-atom transfer (HAT) that drives the reaction forward.
- UPC:
- 51323106
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- SML3488-5MG
- CAS:
- 68341-12-8
