CUTLL1 HUMAN T-CELL LYMPHOMA CELL LINE

Application

T-cell acute lymphoblastic lymphoma (T-ALL) is a rare but aggressive form of non-Hodgkin lymphoma, with a high relapse rate and poor long-term survival (1). The majority of T-cell lymphoblastic leukemias and lymphomas harbors activating mutations in the NOTCH1 gene, a key signaling component required for T-cell development (2). Drugs targeting the Notch pathway are thus promising avenues for treatment of T-cell lymphoblastic leukemias. Lack of response of human T-ALL cell lines to Notch inhibitors has hampered the clinical applicability of these models.

CUTLL1 is a human T-cell lymphoblastic lymphoma cell line derived from a relapsed patient that harbors a t(7;9)(q34;q34) chromosomal translocation resulting in expression of a TCRB-NOTCH1 fusion transcript and aberrant Notch signaling (3). CUTLL1 cells demonstrate high sensitivity to gamma-secretase inhibitors, which act on the Notch pathway. CUTLL1 cells express markers of immature T-cells including CD3, CD4, CD8 and TCRαα (3).

Source:
The CUTLL1 cell line was established from pleural effusion of a relapsed 14-year-old male patient suffering from T-cell lymphoblastic lymphoma (2)

References:
1. Cancer J. 2012; 18(5): 432-8.
2. Science 2004; 306(5694): 269-71.
3. Leukemia 2006; 20(7): 1279-87.

Features and Benefits

The CUTLL1 cell line is a valuable and clinically relevant model for T-cell lymphoblastic lymphoma.

Storage and Stability

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Other Notes

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.