InformationCyclo(RGDyK) Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.TargetsαVβ3 integrin 20 nMIn vitroCyclo(RGDyK) shows high affinity and selectivity for αVβ3 over αVβ5 and αIIbβ3. Cyclo(RGDyK)-conjugated micelles (TPM) facilitated the cell-specific uptake of DiI into B16-F10 cells and HUVECs via integrin-mediated endocytosis compared with Cyclo(RGDyK) -free micelles (NPM).In vivoIn apoE−/− mice, Cyclo(RGDyK) (1 nmol, i.v.) inhibits the increase of αVβ3 integrin expression in the intima of the left stenotic carotid artery. Specification: 0.98 Molecular Formula: C31H43F6N9O12 Molecular Weight: 847.72 PubChem CID: 129896716 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/C413850-SCI_3a5533634535fa0961927fb3a76094c6.pdf
- UPC:
- 51322200
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C413850-5mg
- CAS:
- 250612-42-1
- Product Size:
- 5mg
- Hazard Statement Codes:
- H302:H372:H410
- Precautionary Statement Codes:
- P260:P264:P273:P501
