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Cytochrome c from bovine heart (C15-1290-885)

Catalog No.
C15-1290-885
Manufacturer No.
C2037-100MG
Manufacturer Name
Sigma-Aldrich
Quantity
100
Unit of Measure
MG
Price: $519.80
List Price: $577.55

Cytochrome C is a heme protein. It is localized between the inner and outer mitochondrial membranes.

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General description

Cytochrome C is a heme protein. It is localized between the inner and outer mitochondrial membranes.

Application

Cytochrome c from bovine heart has been used:

  • for cytochrome oxidase staining using the mice brain tissue
  • as a component of control mixture to evaluate the accuracy of tandem mass spectra in identifying peptides
  • to study its effect on the stability, transport, and retention of biochar colloids (BCs) in saturated porous media under various solution pH and ionic strength (IS) conditions
  • as a component of staining solution for the detection of cytochrome oxidase activity in the brain tissue sections of mouse
  • as a component in the assay to study its superoxide scavenging efficiency
  • as a component of serum-free DMEM media to evaluate non-specific cytochrome C reduction in astrocytes and HT-29 cells

Biochem/physiol Actions

Cytochrome C is a key mediator of oxidative phosphorylation. It mediates the electron transport between complex III and complex IV of the respiratory chain.

Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell. Investigation on the effect of Paris Saponin I (PS I) on human gastric carcinoma cell growth (SGC7901 cells) have shown an elevated level cytoplasmic cytochrome c. Results are an inhibition of proliferation in SGC7901 cells by inducing mitochondria-dependent apoptosis through cytochrome.

The ready interconversion of cytochrome c between ferrous and ferric states makes it an efficient biological electron carrier. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal link in the respiratory chain, it forms the essential electron-bridge between the respirable substrates and oxygen.

Preparation Note

Prepared using TCA.

Other Notes

View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.

UPC:
12352207
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
C2037-100MG


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