D-Cl-amidine hydrochloride (C09-1126-855)

D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity.Appearance:SolidIn Vitro:D-Cl-amidine (200-400 μM) is effective in significantly decreasing cell viability in MDA-MB-231 cells. D-Cl-amidine increase caspase 3 activity, indicating that inhibition of PAD1 leads to an increase in apoptosis. MCE has not independently confIn Vivo:D-Cl-amidine, administered by iv at a dose of 2.5mg/kg, is still detected after 2 h in serum at a concentration of ~21 nM and at 4 h at ~10 nM. D-Cl-amidine is still observed in the blood serum at a concentration of ∼10 nM at 4 h when administered by ipBiological Activity:D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity. Specification: 0.99 Molecular Formula: C14H20Cl2N4O2 Molecular Weight: 347.24