Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effectIn VitroDanegaptide (GAP-134, compound 9f; 0.01 nM-100 μM) dose dependently reduces dye uptake in cultured C6 glioma cells in a manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoDanegaptide (GAP-134, compound 9f) is evaluated for in vivo efficacy in the mouse CaCl 2 model after oral administration. For doses of 5-20 mg/kg po, Danegaptide significantly prolongs the time to conduction block in mice after the infusion of CaCl 2 . ?/nDanegaptide (GAP-134) is biologically active upon oral administration at an average plasma concentration of 250 nM, and reduces atrial fibrillation in a dog model. Danegaptide has no effect on heart rate, arterial blood pressure or other electrocardiogram (ECG) parameters. Danegaptide is an effective antiarrhythmic compound in the setting of ischaemia/reperfusion-induced arrhythmogenesis in barbiturate-anesthetized, open-chest beagles. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Gap junction. Specification: 0.99 Molecular Formula: C14H18ClN3O4 Molecular Weight: 327.76 PubChem CID: 44563896 Isomeric SMILES: C1[C@H](CN([C@@H]1C(=O)O)C(=O)CN)NC(=O)C2=CC=CC=C2.Cl
- UPC:
- 51144602
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- D649054-25mg
- CAS:
- 943133-81-1
- Product Size:
- 25mg
