Danegaptide Hydrochloride (C09-1126-657)

Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effectIn VitroDanegaptide (GAP-134, compound 9f; 0.01 nM-100 μM) dose dependently reduces dye uptake in cultured C6 glioma cells in a manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoDanegaptide (GAP-134, compound 9f) is evaluated for in vivo efficacy in the mouse CaCl 2 model after oral administration. For doses of 5-20 mg/kg po, Danegaptide significantly prolongs the time to conduction block in mice after the infusion of CaCl 2 . ?/nDanegaptide (GAP-134) is biologically active upon oral administration at an average plasma concentration of 250 nM, and reduces atrial fibrillation in a dog model. Danegaptide has no effect on heart rate, arterial blood pressure or other electrocardiogram (ECG) parameters. Danegaptide is an effective antiarrhythmic compound in the setting of ischaemia/reperfusion-induced arrhythmogenesis in barbiturate-anesthetized, open-chest beagles. MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:Gap junction. Specifications and Purity: 10mM in DMSO. Molecular Formula: C14H18ClN3O4. Molecular Weight: 327.76.