InformationDarolutamide (ODM-201) Darolutamide (ODM-201, BAY-1841788) is a novel androgen receptor (AR) antagonist that blocks AR nuclear translocation with K i of 11 nM. Phase 3.TargetsAndrogen receptor 11 nM(Ki)In vitroIn AR-HEK293 cells stably expressing full-length hAR, ODM-201 inhibits human AR (hAR) with IC50 of 26 nM. ODM-201 inhibits VCaP cell proliferation with IC50 of 230 nM, while has no effect on the viability of AR-negative cell lines tested, DU-145 prostate cancer cells and H1581 lung cancer cells.In vivoIn mice bearing VCaP xenografts, ODM-201 (50/u2009mg/kg, p.o.) significantly inhibits castration-resistant prostate tumor growth.Cell Research(from reference)Cell lines：DU-145, H1581, and VCaP cells Concentrations：~10 μM Incubation Time：4 days. Specification: 0.99 Molecular Formula: C19H19ClN6O2 Molecular Weight: 398.85 PubChem CID: 67171867 Isomeric SMILES: C[C@@H](CN1C=CC(=N1)C2=CC(=C(C=C2)C#N)Cl)NC(=O)C3=NNC(=C3)C(C)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/D413782-SCI_0699b2a855a5314cefeb65aed6caa09f.pdf
- UPC:
- 12352208
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.97 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- D413782-100mg
- CAS:
- 1297538-32-9
- Product Size:
- 100mg
