Biochem/physiol Actions dCBP-1 is a highly potent and selective bifunctional PROTAC degrader of CREB-binding protein (CBP) and p300 (p300/CBP) that potently inhibits enhancer-mediated transcription. dCBP-1 induces complete loss of p300/CBP in
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dCBP-1 is a highly potent and selective bifunctional PROTAC degrader of CREB-binding protein (CBP) and p300 (p300/CBP) that potently inhibits enhancer-mediated transcription. dCBP-1 induces complete loss of p300/CBP in multiple cellular models of multiple myeloma.
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