DDO-2093 dihydrochloride is a potent MLL1-WDR5 protein-protein interaction inhibitor ( IC 50 =8.6 nM; K d =11.6 nM) with antitumor activity. DDO-2093 dihydrochloride selectively inhibits the catalytic activity of MLL complex.Appearance:SolidIn Vitro:DDO-2093 (5 μM; pretreated 7 days) dihydrochloride inhibits MLL-fusion protein dependent genes expression ( HOXA9 and Meis1 ). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCIn Vivo:DDO-2093 (20-80mg/kg; i.p.; every other day for 21 days) dihydrochloride significantly suppresses the tumor size and weight in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. ABiological Activity:DDO-2093 dihydrochloride is a potent MLL1-WDR5 protein-protein interaction inhibitor ( IC 50 =8.6 nM; K d =11.6 nM) with antitumor activity. DDO-2093 dihydrochloride selectively inhibits the catalytic activity of MLL complex. Specification: 0.98 Molecular Formula: C29H39Cl3FN9O3 Molecular Weight: 687.04
- UPC:
- 12352107
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.09 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- D658611-10mg
- Product Size:
- 10mg
