DDP-38003 trihydrochloride (C09-1126-797)

DDP-38003 trihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A ( KDM1A/LSD1 ) with an IC 50 of 84 nM.Appearance:SolidIC50& Target:IC50: 84 nM (KDM1A/LSD1)In Vitro:DDP-38003 inhibits KDM1A with an IC 50 of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue. MCE has not independently confirmed the accuracy of thIn Vivo:DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obBiological Activity:DDP-38003 trihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A ( KDM1A/LSD1 ) with an IC 50 of 84 nM. Specifications and Purity: 98%. Molecular Formula: C21H28Cl2N4O. Molecular Weight: 423.38. PubChem CID: 102004295. Isomeric SMILES: CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=CC=C(C=C3)[C@@H]4C[C@H]4N.Cl.Cl.