DDR1-IN-6 (C09-1126-065)

DDR1-IN-6 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC 50 of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with an IC 50 of 9.7 nM. DDR1-IN-6 has anti-cancer activityIn VitroDDR1-IN-6 (compound 1; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC 50 =13 nM). DDR1-IN-6 (72 hours) has cytotoxicity in LX-2 cells (CC 50 =3 μM). DDR1-IN-6 (0-30 μM) has anti-proliferation effects on primary tumor cells freshly isolated from PC-07-0024 (IC 50 =5.7 μM of 3 days; IC 50 =2.65 μM of 6 days) and LU-01-0523 derived xenograft (PDX) tumor model (IC 50 >30 μM of 3 days; IC 50 >30 μM of 6 days). MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:DDR1 9.72 nM (IC 50 ). Specification: 0.98 Molecular Formula: C23H14F3N5O Molecular Weight: 433.39