Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs) . Desethyl chloroquine diphosphate possesses antiplasmodic activityIn VivoIntraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Plasmodium TLRs. Specification: 0.99 Molecular Formula: C16H28ClN3O8P2 Molecular Weight: 487.81 PubChem CID: 49849615 Isomeric SMILES: CCNCCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O
- UPC:
- 51332205
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- D648246-10mg
- CAS:
- 247912-76-1
- Product Size:
- 10mg
