Desloratadine (C09-0844-986)

Desloratadine is a potent and selective histamine H1-receptor agonist with a half life of 21-24 hours. Experiments suggest that this compound also exerts antioxidant effects in vitro. Other studies show that H1-receptor binding by desloratadine is reversible and that, over time, desloratadine dissociates from membrane H1-recepters. Desloratadine has also demonstrated the ability to block ICAM-1 upregulation and NFκB activation in primary bronchial and transformed respiratory epithelial cells in vitro.It is a potent antagonist for human histamine H1 receptor used to treat allergies. Specification: >98.0%(HPLC)(T) MDL Number: MFCD00871949 Molecular Formula: C19H19ClN2 Molecular Weight: 310.83 PubChem CID: 124087 Isomeric SMILES: C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/D155989-SCI_e6e72b4956a9392f118ffe238706b6f7.pdf