Desmosine is a tetrafunctional, pyridinium ring-containing amino acids involved in elastin cross-linking. A desmosine cross-link is formed from three allysyl side chains plus one unaltered lysyl side chain from the same or neighbouring polypeptides. Desmosine is responsible for the cross-linking of elastin leading to the formation of insoluble fibers. Urinary excretion of desmosine is a useful indicator of elastin breakdown resulting from increased elastase activity. It also acts as a biomarker of elastin degradation in chronic obstructive. Desmosine is prepared according to the method of Starcher et al. from hydrolyzed neck ligament by solvent extraction and chromatography on Dowex 50.
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- UPC:
- 51241518
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 0219137805
- Model Number:
- C823L20
- Temperature Control Device:
- Yes
