General description
Dess-Martin periodinane (DMP) is a hypervalent iodine compound widely used as a mild reagent for the oxidation of primary/secondary alcohols to aldehydes/ketones; oxidation of amides into imides; the dehydrogenation of amines to nitriles, and disulfides to sulfones. It is also used to selectively oxidize alkenes to epoxides. This is a useful reaction for generating three-membered cyclic ethers. Additionally, DMP is used to oxidatively cleave 1,2-diols to form aldehydes or ketones and in the synthesis of lactones.
Application
Dess–Martin periodinane is used as an oxidizing agent:
- For 1° and 2° alcohols to aldehydes and ketones.
- In the synthesis of N-protected α-amino aldehydes from the corresponding N-protected β-amino alcohols.
- To synthesize alkynyl oxoaldehyde probe (AlkMGO).
Used for the oxidation of hydroxychlorins to chlorin-α-diones and tetraones.
Features and Benefits
Benefits of using DMP as an oxidizing reagent:
- milder reaction conditions (room temperature, neutral pH)
- shorter reaction times and higher yields
- high chemoselectivity
- tolerance of sensitive functional groups, and a long shelf life
- simplified workups
- UPC:
- 51352004
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 274623-250G
