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DIACYLGLYCEROL KINASE INHIBI 1PC X 5MG (C005B-090606)

Catalog No.
C005B-090606
Mfr. No.
266785-5MG
Mfr. Name
Sigma-Aldrich
Qty/UOM
5
UOM
MG
Price: $351.97
List Price: $391.07

Potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC 50 = 2.

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General description

Potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC50 = 2.8 µM) without affecting phosphodiesterase or phosphatidylinositol kinase. Potentiates this effect in studies of signal-transducing inositol lipid metabolism. Inhibits human platelet DAG kinase in intact cells (IC50 = 3.6 µM) and in isolated membranes (IC50 = 6.7 µM). In porcine thymus cytosol it inhibits the 80 kDa DAG kinase (IC50 = 10 µM) but has no effect on the 150 kDa DAG kinase. Weak dopamine D2 and histamine H1 antagonist and strong serotonin-S2 antagonist.

Potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC50 = 2.8 µM) without affecting phosphodiesterase or phosphatidylinositol kinase. Weak dopamine D2 and histamine H1 antagonist and strong serotonin S2 antagonist.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Diacylglycerol Kinase

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.

Other Notes

Goin, M., et al. 1993. FEBS Lett. 316, 68.
Ohtsuka, T., et al. 1990. J. Biol. Chem.265, 15418.
de Chaffoy de Courcelles, D., et al. 1985. J. Biol. Chem.260, 15762.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:
51321602
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
MPN:
266785-5MG
CAS:
93076-89-2

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