Application
Maleimide functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into thiol containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.
Applications Include:
- Protein-peptide conjugates
- Antibody-enzyme or antibody-drug conjugates
- Protein or peptide-oligonucleotide conjugates
- Surface modification
Molecular Weight: 427.45. Empirical Formula: C
25H
21N
3O
4. Quality Level: 100. form: solid. reaction suitability: reaction type: click chemistry, reagent type: cross-linking reagent. functional group: maleimide. storage temp.: −. 20°C. SMILES string: O: C(N1CCC(NCCC(N2CC3: C(C: CC: C3)C#CC4: C2C: CC: C4): O): O)C: CC1: O. InChI: 1S/C25H21N3O4/c29-22(14-16-27-23(30)11-12-24(27)31)26-15-13-25(32)28-17-20-7-2-1-5-18(20)9-10-19-6-3-4-8-21(19)28/h1-8,11-12H,13-17H2,(H,26,29). InChI key: NHFQNAGPXIVKND-UHFFFAOYSA-N. Pictograms: GHS09. Signal Word: Warning. Hazard Statements: H400. Precautionary Statements: P273. Hazard Classifications: Aquatic Acute 1. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.