General description
N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.
Application
N,N′-Diisopropylcarbodiimide can be used:
- To synthesize lanthanide (Ln) guanidinate complexes via insertion of carbodiimide into the Ln-N bond of lanthanocene secondary amido complexes.
- To facilitate the cyclization of N-(β-Hydroxy)amides to form 2-oxazolines.
- To synthesize 1-isopropyl-2-alkoxycarbonyl-3-isopropyliminio-aziridine by reacting with alkyl diazoacetates in the presence of transition metal salts.
DIC can be used as:
- A coupling reagent for the synthesis of various esters and amides by treating carboxylic acids with phenols and amines respectively.
- A reagent for the conversion of alcohols to aldehydes or ketones in the presence of DMSO via modified Moffatt-type oxidation reaction.
- A reagent to facilitates the preparation of alkyl halides from corresponding alcohols via the formation of o-alkylisourea.
Alternative to dicyclohexylcarbodiimide in peptide synthesis.
- UPC:
- 51131613
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 38370-100ML
