General description
DPPIV is involved in many cellular processes such as activation of cytokines, differentiation, and cell-matrix interactions. Inhibition of DPPIV has been reported to be an effective treatment for type II diabetes.
Note: 1 mU = 1 milliunit.
Recombinant, human DPP IV fused at the N-terminus to a His•Tag
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Standard Handling (A)
Unit Definition
One unit is defined as the amount of enzyme that will hydrolyze 1 µmole H-Gly-Pro-AMC per min at 37°C, pH 8.0.
Physical form
In 20 mM Tris-HCl, 5 mM CaCl₂, 1 µM ZnCl₂, 0.05% NaN₃, pH 8.0.
Reconstitution
Following initial thaw, aliquot and freeze (-70°C).
Other Notes
Pospisilik, JA, et al. 2003. Diabetes52, 741.
Dobers, J., et al. 2002. Protein Expr. Purif.25, 527.
Marguet, D., et al. 2000. Proc. Natl. Acad. Sci.97, 6874.
Misumi, Y., et al. 1992. Biochim. Biophys. Acta1131, 333.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Quality Level: 100. Assay: ≥. 90% (SDS-PAGE). form: liquid. specific activity: ≥. 8 . units/mg protein. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, avoid repeated freeze/thaw cycles. shipped in: wet ice. storage temp.: −. 70°C.- UPC:
- 12352202
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 317639-5MIU