DIQUAT METABOLITE MONOPYRIDONE

General description

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com

Diquat monopyridone is a common degradation product of Diquat. Diquat is a nonselective, defoliant, preharvest, and desiccant herbicide that belongs to the bipyridinium class. Diquat can rapidly penetrate through the leaf surface but is not taken up by the roots, due to its strong adsorption onto the soil particles. Its activity is based on the liberation of the superoxide anion radical, followed by hydrogen peroxide, causing tissue destruction by oxidative stress. The herbicidal activity of diquat is more pronounced in daylight, aerobic conditions, high humidity, and temperature.

Diquat is not approved for its use in the European Union. The maximum residue limit (MRL) for diquat presence in the crops varies between 0.05 mg/kg in most of the commodities to 10 mg/kg for linseed and barley.

The EU residue definitions are broader, however, the toxicological data is still missing for the diquat metabolites, monopyridone and dipyridone, to compare their toxicity with the parent compound.

Application

The certified reference material (CRM) is intended to be used as a calibrant for chromatography and other analytical techniques. The CRM may also find following uses:

• Detection of two diquat metabolites in urine and serum of poisoned patients after ingestion of combined herbicides, paraquat and diquat
• Analysis of paraquat, diquat, and two diquat metabolites in biological materials by high-performance liquid chromatography coupled with UV and fluorescence detectors

Legal Information

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