Amino Acid Sequence
Cer-Glc-Gal(NeuAc-NeuAc)-GalNAc
General description
Disialoganglioside GD2 is a cell surface-associated glycosphingolipid, which comprises sialic acid moiety and is regarded as a carbohydrate antigen.. It is expressed in the skin melanocytes, central and peripheral nervous system.
Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.
Application
Disialoganglioside-GD2 from bovine brain has been used:
- in the ganglioside- enzyme-linked immunosorbent assay (ELISA)
- in capture ELISA with anti-GD2 antibody (ch14.18)
- as a control to test its effect on reactivating autophagy in primary fibroblasts
Biochem/physiol Actions
Disialoganglioside GD2 is expressed in neuroblastoma, melanoma and small cell lung cancer. It is an immunotherapeutic target and is also regarded as a tumor-associated antigen. GD2 may favor cell migrationin tumors by promoting cell growth, as well as extracellular matrix component attachment.
- UPC:
- 51142029
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G0776-.1MG
