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dl-buthionine-(s,r)-sulfoximine (c15-1244-750)

DL-Buthionine-(S,R)-sulfoximine (C15-1244-750)

Sigma-Aldrich

Catalog No.
C15-1244-750
Manufacturer No.
B2640-500MG
Manufacturer Name
Sigma-Aldrich
Quantity
500
Unit of Measure
MG
Price: $295.71
List Price: $328.57

DL -buthionine- SR -sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.

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General description

DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.

Application

DL-Buthionine-(S,R)-sulfoximine has also been used:

  • to induce oxidative stress in Starlings
  • to deplete choroidal glutathione (GSH) in two-day-old rat pups
  • to test its inhibitory effect on the enzymes, γ-glutamylcysteine synthetase and trypanothione synthetase (TryS) from T. cruzi

DL-Buthionine-(S,R)-sulfoximine has been used to deplete cellular glutathione levels in retinal ganglion cell 5 (RGC-5) cell line.

Biochem/physiol Actions

Depletes cellular glutathione and downregulates GST level.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

UPC:
51283952
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
B2640-500MG


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