DL-threo-Dihydrosphingosine

DL-threo-Dihydrosphingosine is an inhibitor of Sphk (sphingosine kinase). This inhibitory activity has been employed as a tool for identifying the activity of sphingosine kinase in various processes. A role of sphingosine-1-phosphate generated by sphingosine kinase is suggested in the mobilization of Ca|2+|stimulated by local discrete increases in intracellular Ca|2+|at m|2|and m|3|muscarinic acetylcholine receptors. DL-threo-Dihydrosphingosine demonstrates inhibition of Ca|2+|mobilization, and modulation of this process is suggested to function as an amplification for Ca|2+|signals mediated by sphingosine kinase activity. The extracellular signal-regulated kinase (ERK) pathway is inhibited by DL-threo-Dihydrosphingosine, suggesting participation of sphingosine kinase in this pathway. DL-threo-Dihydrosphingosine was demonstrated to increase the sensitivity of HEK-293 cells to fumonisin B1cytotoxicity, indicating that fumonisin B1 resistance in HEK-293 cells involves rapid formation of sphingosine-1-phosphate by sphingosine kinase which confers survival properties to the cells. Specification: 0.98 Molecular Formula: C18H39NO2 Molecular Weight: 301.51 PubChem CID: 5746414 Isomeric SMILES: CCCCCCCCCCCCCCC[C@H]([C@@H](CO)N)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/D342407-SCI_dff67b0184f42fb915416ab83ad6b0fc.pdf