General description
DMT-2′O-TBDMS-rC(ac) Phosphoramidite belongs to the group of 2′O-TBDMS RNA Phosphoramidites.
Application
RNA interference (RNAi) has become a popular tool for the sequence-specific inhibition of gene expression and can be used in target validation and other drug development techniques. The most convenient method to provide sequence-specific RNA oligonucleotides is a chemical synthesis on a solid support with RNA phosphoramidites and RNA CPG, analogous to DNA synthesis.
Features and Benefits
Its key features include:
- Industry standard 2′O-TBDMS protective group
- Consistent lot-to-lot purity and performance
- Compatible with deprotection methods based on methylamine or AMA
- Standard RNA phosphoramidites provide excellent coupling results when used with ETT or BTT as an activator; best results are obtained with Activator 42
- Capping with standard acetic anhydride capping reagent rather than with Fast Deprotection Cap A
- Manufactured under a certified ISO 9001 quality system
Other Notes
The unique properties of RNA have stimulated the development of a variety of applications in diagnostics and therapeutics, as well as in basic molecular biology research where RNA can be used as:
- Catalytic agents (ribozymes)
- Affinity ligands (aptamers)
- Agents to induce gene silencing (RNA interference)
- UPC:
- 51151524
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C213000-100G
