DNA-PK Inhibitor III (C09-0856-892)

DNA-PK Inhibitor III is a cell-permeable aryl-morpholino compound that is potent, selective, and an ATP-competitive inhibitor of DNA-PK (IC|50|= 120 nM) and PI 3-Kinase catalytic subunit p110β (IC|50|= 135 nM). Inhibits DNA-PK-mediated cellular DNA DSB (double strand break) repair (EC|50|= 68 μM) and enhances DSB-induced antitumor activity|in vitro|, while exhibiting no cytotoxic effects (up to 50 μM) in the absence of DSBs. Also inhibits PI 3K p110α, p110γ, and p110δ only at much higher concentrations (IC50= 1.4 μM, 880 nM, and 1.0 μM, respectively) and exhibits no effect against a panel of several other kinases, including, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12, even at concentrations as high as 100 μM. Specification: ≥95% Molecular Formula: C12H15NO3 Molecular Weight: 221.26 PubChem CID: 9859309 Isomeric SMILES: CC(=O)C1=C(C=C(C=C1)N2CCOCC2)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/D337628-SCI_1dae8d6e6a8f07924e59a277f5f37a36.pdf