Rabbit anti Human DNAJC2/ZRF1 Antibody, Polyclonal, could be used for WB, IHC and so on.ApplicationWB: 0.01-2 μg/mLIHC: 5-20 μg/mLProtein FunctionActs both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'. Specifications and Purity: pAb; Rabbit anti Human DNAJC2/ZRF1 Antibody; WB, IHC; Unconjugated.
- UPC:
- 12352203
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- Ab100171-10μl
- Product Size:
- 10μl
