A highly potent inhibitor of p38 MAPK (Kd = 0.1 nM) that blocks TNF&alpha release in LPS-stimulated THP-1 cells with an IC50 value of 18 nM At 10 &muM, inhibits JNK2&alpha2 in vitro.
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A highly potent inhibitor of p38 MAPK (Kd = 0.1 nM) that blocks TNFα release in LPS-stimulated THP-1 cells with an IC50 value of 18 nM; At 10 μM, inhibits JNK2α2 in vitro.
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