Dotarizine is a broad spectrum Ca|2+|antagonist and calcium channel protein inhibitor which blocks calcium uptake, [Ca|2+|]i rise and secretion via blockade of calcium channels. In addition, dotarizine selectively binds to vascular 5-HT receptors, blocking Ca|2+|activated Cl|-|channels. Dotarizine is a piperazine derivative structurally related to flunarizine, which accounts for the similar function of the two compounds. Furthermore, flunarizine is a less selective antagonist than dotarizine towards SR (5-HT receptors). Alternate studies indicate that dotarizine can inhibit cell death in bovine adrenal medullary chromaffin cells by decreasing cytosolic Ba|2+|concentration via Ca|2+|channel blockade. Specification: >98% Molecular Formula: C29H34N2O2 Molecular Weight: 442.59 PubChem CID: 55285 Isomeric SMILES: C1CN(CCN1CCCC2(OCCO2)C3=CC=CC=C3)C(C4=CC=CC=C4)C5=CC=CC=C5 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/D336031-SCI_408d0b7e4e641a95ff3bd62ee931fbfb.pdf
- UPC:
- 51142419
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- D336031-5mg
- CAS:
- 84625-59-2
- Product Size:
- 5mg
- Precautionary Statement Codes:
- P264
