Dowtherm(R) A (C15-1303-650)

General description

Dowtherm^® A is a thermally stable organic heat transfer fluid composed of a eutectic mixture of highly stable compounds, biphenyl, and diphenyl oxide. Dowtherm^® A is suitable for high-temperature heat transfer applications up to 400 °C. This fluid can be used in both liquid and vapor phase systems.

Application

Dowtherm^® A can be used as a high boiling solvent in cyclization reactions. For example, it is used to synthesize:      

• 1-Hydroxy-5-methoxy-1,2-dihydrobenzo[f][2,7]naphthyridines from 2-chloro-3-formyl quinolines.     
• Isoindolinone derivatives via intramolecular Diels–Alder cycloaddition reactions of substituted pyridazines.
• Phosphorylated azaheterocycles from 2-diethoxyphosphoryl-3-methoxyacrylate via intramolecular cyclizations under thermal conditions.

Legal Information

DOWTHERM is a registered trademark of The Dow Chemical Company or an affiliated company of Dow

Quality Level: 100. refractive index: n20/D 1.590. mp: 12-14 . °C (lit.). SMILES string: c1ccc(cc1)-c2ccccc2.O(c3ccccc3)c4ccccc4. InChI: 1S/C12H10O.C12H10/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12. 1-3-7-11(8-4-1)12-9-5-2-6-10-12/h1-10H. 1-10H. InChI key: MHCVCKDNQYMGEX-UHFFFAOYSA-N. Pictograms: GHS07,GHS09. Signal Word: Warning. Hazard Statements: H315 - H319 - H335 - H410. Precautionary Statements: P261 - P264 - P271 - P273 - P302 + P352 - P305 + P351 + P338. Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3. Target Organs: Respiratory system. Storage Class Code: 10 - Combustible liquids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type ABEK (EN14387) respirator filter.