Apramycin

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Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC 50 = 50 pM). Prevents the translational activation of IGF-II.

Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC 50 = 50 pM). Prevents the translational activation of IGF-II.

Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1