Novobiocin calcium

A cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK.

A cell permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC 50 =

A cell permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC 50 =

A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition &lt5 M) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell

Cell-permeable inhibitor of calpain I (K i = 190 nM), calpain II (K i = 220 nM), cathepsin B (K i = 150 nM), and cathepsin L (K i = 500 pM). Inhibits neutral cysteine proteases and the proteasome (K i = 6 &#181M).

Cell-permeable inhibitor of calpain I (K i = 190 nM), calpain II (K i = 220 nM), cathepsin B (K i = 150 nM), and cathepsin L (K i = 500 pM). Inhibits neutral cysteine proteases and the proteasome (K i = 6 &#181M).

A polypeptide composed of 74 amino acids containing 5 disulfide bridges. Blocks neuromuscular transmission by irreversible binding to the motor end-plate acetylcholine receptor (K d = 1 nM to 1 pM) but does not depress acetylcholine release from

A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC 50 = 25.1, 148, and 234.

A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC 50 = 25.1, 148, and 234.

A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC 50 = 25.1, 148, and 234.

A cell-permeable inhibitor of apoptosis induction (IC 50 = 67 &#181g/ml in FasL-stimulated WC8 cells, 130 &#181g/ml in etoposide-stimulated U937 cells). Effects attributable to the inhibition of caspase-3 activation but does not directly inhibit

Recombinant, bovine aprotinin supplied without animal-derived components. Aprotinin is a competitive, reversible inhibitor of proteolytic and esterolytic activity.