Novobiocin calcium

A cocktail of six protease inhibitors with broad specificity for the inhibition of aspartic, cysteine, and serine proteases as well as aminopeptidases. This cocktail is recommended for use with mammalian cell and tissue extracts.

An uncharged, 1,4-di-substituted, phenyl-linked bis -trifluoromethylsulfonamido (TFMS) phosphate mimetic that acts as a potent, reversible, competitive, and active-site directed inhibitor of protein tyrosine phosphatases (PTP IC 50 = 1.8, 2.

A cell-permeable thiazolidinedione compound that is shown to inhibit the enzymatic activity of PTP1B, SHP-1, YOP, TC-PTP, and YPTP1 (IC 50 = 5, 5.8, 6, 16, and 18 &#181M, respectively), but not that of LAR even at concentrations as high as 100

A phenolic product found in both grape skin and wines. Has anti-fungal, anti-tumor and antioxidative properties.

A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC 50 = 27 and 32 &#181M for human and S. cerevisiae RNA Pol III, respectively).

A cell permeable, Sulindac analog with IC 50 =2.4 &#181M for RXR&#945 binding, and unlike other NSAIDs, is inactive toward COX2 and COX1 even at 1 mM.

A diphenylsulfone-sulfonamide compound that counteracts the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and Wnt-3/frizzled-stimulated cellular functions (EC 50 = 1.27 &#181M in a

A cell-permeable 2-hydroxy-1-naphthaldehyde derivative that acts as a specific and direct inhibitor of the sirtuin class of deacetylase activity with no affect on human HDAC1 (IC 50 = 48 &#181M, 131 &#181M and 58 &#181M for ySir2, hSIRT1 and

A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is

A cell-permeable oxindole compound that acts as a potent, reversible, and ATP-competitive Syk inhibitor (IC 50 = 14 nM). Has been shown to effectively inhibit Fc&#949RI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC

A cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC 50 = 2.5 &#181M).

Dissolving one tablet in 500 ml of deionized water yields 150 mM NaCl, 0.05% TWEEN &#174 20 Detergent, 50 mM Tris-HCl buffer, pH 7.