Sulfamazone

Other Notes Please note that Sigma-Aldrich provides this product to early discovery researchers as part of a collection of rare and unique chemicals. Sigma-Aldrich does not collect analytical data for this product.

Other Notes Please note that Sigma-Aldrich provides this product to early discovery researchers as part of a collection of rare and unique chemicals. Sigma-Aldrich does not collect analytical data for this product.

A potent and specific inhibitor of vertebrate collagenases with IC 50 values in the micromolar range. A potent and specific inhibitor of vertebrate collagenases with IC 50 values in the order of 1 &#181M.

Consanguineous: No Homozygous: No Cell Line Description This cell line is an Epstein-Barr Virus (EBV) transformed lymphoblastoid line and is part of the Human Leukocyte Antigen (HLA) Typed Collection maintained by the European Collection of Cell

A zwitterionic detergent. Lauryldimethylbetaine is useful as a detergent for solubilization of membrane components and for preparation of viral agents.

A potent, reversible, broad range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC 50 = 24 nM), MMP-3 (IC 50 = 18.

A dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC 50 = 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC 50 = 160, 320

A potent inhibitor of MMP-13 activity (IC 50 = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a

A cell-permeable, potent inhibitor of human MMP-3 (stromelysin K i = 130 nM). A potent and cell-permeable inhibitor of human MMP-3 (K i = 130 nM).

A cell-permeable and highly, piperazine-based potent inhibitor of MMP-9 (IC 50 = 900 pM) and MMP-13 (IC 50 = 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC 50 = 43 nM and 23 nM, respectively).

A cell-permeable thiazolidinedione compound that acts as a potent, selective, and ATP-competitive inhibitor of phosphatidylinositol 3-kinase &#947 (PI 3-K&#947) (K i = 7.8 nM IC 50 = 8 nM, 60 nM, 270 nM, 300 nM for p110-&#947, &#945, &#946

A cell-permeable thiazolidinedione compound that acts as a potent and ATP-competitive inhibitor of PI 3-K&#947 (K i = 180 nM IC 50 = 250 nM). Exhibits great selectivity over PI 3-K&#945 (IC 50 = 4.