Antineoplastic agents

Potent anticancer compound. Anti-angiogenic.

Biochem/physiol Actions (-)-Epothilone A is a microtubule (MT) stabilizing drug and natural macrolide antitumor from myxobacteria Sorangium cellulosum . EpoA exhibits kinetics similar to paclitaxel by inducing tubulin polymerization in vitro and

Epothilones has antimitotic properties. It prevents microtubule depolymerization and competitively blocks paclitaxel binding to microtubules.

Epothilones has antimitotic properties. It prevents microtubule depolymerization and competitively blocks paclitaxel binding to microtubules.

Application Catalyst for C-C and C-N coupling reaction. Pd(dppf)Cl 2 may be used as an effective palladium catalyst in the following reactions: Cross-coupling of sec -alkyl and n -alkyl Grignard reagents with high yield and selectivity.

Application Catalyst for C-C and C-N coupling reaction. Pd(dppf)Cl 2 may be used as an effective palladium catalyst in the following reactions: Cross-coupling of sec -alkyl and n -alkyl Grignard reagents with high yield and selectivity.

Other Notes Please note that Sigma-Aldrich provides this product to early discovery researchers as part of a collection of unique chemicals. Sigma-Aldrich does not collect analytical data for this product.

Application (1-Ethoxycyclopropoxy)trimethylsilane was used in the preparation of N -(1&#8242-alkoxy)cyclopropyl-2-haloanilines.

Application (1 R )-(&#8722)-Camphorquinone can be used as a chiral starting material for the preparation of: &#945-Hydroxycamphors by selective reduction of keto groups using various vegetables. Camphor-1,2-diamine platinum(II) complexes for DNA

Other Notes Please note that Sigma-Aldrich provides this product to early discovery researchers as part of a collection of unique chemicals. Sigma-Aldrich does not collect analytical data for this product.

Other Notes Please note that Sigma-Aldrich provides this product to early discovery researchers as part of a collection of unique chemicals. Sigma-Aldrich does not collect analytical data for this product.

Application This lactam and its antipode are precursors to the enantiomers of the carbocyclic nucleoside carbovir. It has been demonstrated that (-)-carbovir is a potent inhibitor of HIV-1 and based on clinical trials it could become an alternative