Tyrosine kinase inhibitors

Synonym(s): BIO-Acetoxime, (2'Z,3'E)-6-Bromoindirubin-3'-acetoxime Formula: C18H12BrN3O3 Formula weight: 398.21 CAS Number: 740841-15-0 Harmonized Tariff Code:  2934.

GSK3&beta Inhibitor II is a potent inhibitor of glycogen synthase kinase-3&beta (GSK3&beta IC₅₀ = 390 nM) that does not inhibit GSK-3&alpha. Also referred to as tip-oxadiazole, this compound blocks the functional regulation of p53 by

GSK3&beta Inhibitor II is a potent inhibitor of glycogen synthase kinase-3&beta (GSK3&beta IC₅₀ = 390 nM) that does not inhibit GSK-3&alpha. Also referred to as tip-oxadiazole, this compound blocks the functional regulation of p53 by

A selective, ATP-competitive inhibitor of the serine/threonine kinase, glycogen synthase kinase 3&beta (Ki = 38 nM IC₅₀ = 104 nM) demonstrates neuroprotective effects by inhibiting tau phosphorylation (IC₅₀ = 2.7 &muM) at a

A selective, ATP-competitive inhibitor of the serine/threonine kinase, glycogen synthase kinase 3&beta (Ki = 38 nM IC₅₀ = 104 nM) demonstrates neuroprotective effects by inhibiting tau phosphorylation (IC₅₀ = 2.7 &muM) at a

A cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (K i = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKC&#948, and SGK only at much higher concentrations (K

A cell permeable indolo[2,3-c]quinoline derivatived compound that acts as a selective and highly potent inhibitor of interleukin-1 receptor associated kinase (IRAK4 IC 50 = 94 pM). Displays much reduced potency against IRAK1 (IC 50 = 65 nM) and

Application Potent inhibitor of p38 alpha/SAPK2a and p38 beta/SAPK2b kinases. The p38/SAPK2 Inhibitor (SB 202190) controls the biological activity of p38/SAPK2.

Application Highly specific inhibitor of p38/SAPK2 Biochem/physiol Actions Inhibitor Type: Kinase Protein Target: p38/SAPK2 Target Sub-Family: CMGC Quality Routinely evaluated in a kinase assay. Physical form C 12 H 16 FN 3 OS Storage and Stability

A cell-permeable bis (1H-2-indolyl)-1-methanone compound that acts as a highly selective, ATP-competitive and reversible inhibitor of platelet-derived growth factor (PDGF) receptor tyrosine kinase (IC 50 = 1.1 M in Swiss 3T3 cells for PDGFR).

A cell-permeable pyrrolopyrimidamine compound that acts as a highly potent EIF2AK3/PERK inhibitor (IC 50 = 0.4 nM [ATP] = 5 &#181M) by targeting PERK in its inactive DFG conformation at the ATP-binding region, while displaying &#8805385-fold

A non-metal complexing, zwitterionic buffer with mixed-mode dissociation constants of pK a1 = 3.73 and pK a2 = 7.