Fluorometholone acetate

2,2-Difluoro-2-(fluorosulfonyl)acetic acid reagent is employed as a difluorocarbene source for difluoromethylation of phenolic hydroxyl groups. Application 2,2-Difluoro-2-(fluorosulfonyl)acetic acid may be used in the following processes:

2,2-Difluoroethyl Acetate.

2，3-Difluoro-4-(trifluoromethyl)acetophenone.

2，3-Difluoro-4-(trifluoromethyl)acetophenone.

2，3-Difluoro-4-(trifluoromethyl)acetophenone.

2，3-Difluoro-6-methoxyphenol.

2-(2，4-difluorophenyl)-1-(4-fluorophenyl)ethanone.

2-(2，4-difluorophenyl)-1-(4-fluorophenyl)ethanone.

2-(2，4-difluorophenyl)-1-(4-fluorophenyl)ethanone.

2-(2-Fluoro-5-methoxyphenyl)acetic acid.

2-(2-Fluoro-5-methoxyphenyl)acetic acid.

2-(3-Chloro-4-fluorophenoxy)acetic acid.