Androgens and androgen inhibitors

A cell-permeable morpholinyl thiazole compound that selectively binds to the DNA-binding domain of androgen receptor (AR) and blocks its activity (IC 50 = 340 nM in PC3 cells). Its inhibitory effect is comparable to enzalutamide (IC 50 = 314 nM).

Androsterone is a tetracydic compound which forms mono-esters or mono-oxime with one hydroxyl group and one keto group respectively. Application Androsterone has been used as working reference standard in identifying natural androgen steroids using

A cell permeable compound that selectively binds to STAT3 and inhibits its DNA binding activity (IC&#8325&#8320 = 13.8 &#181M) and reduces the expression of STAT3 dependent genes.