Immunomodulating drugs

Specificity Recognizes phosphorylatedAkt1/PKB&#945 at Ser473. This lot of antibody does not cross-react with Akt1/PKB&#945 dephosphorylated at Ser473.

Specificity Alpha Synuclein, phospho Serine 129. The antibody recognizes a protein of ~15 kDa corresponding to alpha synuclein, phospho Serine 129 in lysates from rat cortex.

Amyloid precursor proteins (APPs) are transmembrane glycoproteins that are found in a wide range of tissues. APPs have 3 main isoforms, namely, APP695, APP751 and APP770 that are derived from alternative splicing events in cells.

&#946-arrestin-1 is a scaffold protein that is highly expressed in the central nervous system. This adaptor protein regulates mitogenic signaling, and also mediates the desentization and internalization of G protein coupled receptors (GPCRs).

Bid is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators.

c-Abl is a proto-oncogene of the Src family of non-receptor tyrosine kinases. It is a cellular homologue of Ablelson murine leukemia virus, and is implicated in many important cellular processes and tumorigenesis.

MET, a gene for receptor tyrosine kinase, was first isolated in human osteosarcoma-derived cell line. Hepatocyte growth factor (HGF) has been identified as the natural ligand for the c-Met receptor protein.

Cofilin is a small phosphoinositide-sensitive actin-binding protein capable of depolymerizing actin-filaments in vitro . It has gelsolin-like actin filament-severing protein similar to destrin/ADF (Actin Depolymerizing Factor).

Cortactin is encoded by the CTTN gene on chromosome 11 in humans. It is a cytoskeleton protein that facilitates assembly of cortical actin.

Specificity CPI-17 phosphorylated on Threonine 38. Immunogen Peptide corresponding to amino acids 35-46 of human CPI-17.

CYLD is a deubiquitinating enzyme that inactivates transcription factor NF-kappaB using TNFRs and is essential for normal cellular homeostasis of skin appendages. Deactivation or mutation of CYLD causes a loss of the deubiquitination activity and

DARPP32 is a phosphoprotein with a molecular mass of 32kDa. It is regulated by dopamine (DA) and cAMP and is associated with dopaminoceptive neurons bearing D-1 receptors in the basal ganglia.