General description
A cell-permeable phthalimide compound that is reported to inhibit dynamin GTPase activity (IC50 = 17.4 and 63 µM using purified sheep brain dynamin I and recombinant dynamin II, respectively) in a GTP-competitive manner. Shown to block K+-induced SVE (synaptic vesicle endocytosis) of FM4-64 dye into rat brain synaptosomes (IC50 = 12.9 µM), while being ineffective at 30 µM against RME (receptor-mediated endocytosis) of transferrin into human osteosarcoma epithelial U2OS cells, presumably due to poor dynamin II inhibitory potency and/or rapid efflux and/or limited permeability in this cell line.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Odell, L.R., et al. 2010. J. Med. Chem.53, 5267.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 465.80. Empirical Formula: C22H12ClN3O7. Assay: ≥. 98% (HPLC). Quality Level: 100. form: solid. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, protect from light. color: light yellow to beige. solubility: DMSO: 7 . mg/mL. shipped in: ambient. storage temp.: 2-8°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 51172124
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 324412-10MG
