E7766 diammonium salt (C09-1131-134)

E7766 diammonium salt is a macrocycle-bridged STING agonist with a K d of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities.In VitroE7766 diammonium salt inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC 50 values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoIn murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 diammonium salt in the subcutaneous tumor. E7766 diammonium salt is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid. Specifications and Purity: 99%. Molecular Formula: C24H32F2N12O8P2S2. Molecular Weight: 780.66.