Application
Protein degrader builiding block E7820-PEG3-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a DCAF15-recruiting ligand E7820 (SML2950 ), a PEG linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Protein Degrader Building Blocks
Technology Spotlight: DCAF15 Degrader Building Blocks for Targeted Protein Degradation
Other Notes
In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15
E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Molecular Weight: 529.61 (free base basis). Empirical Formula: C25H31N5O6S · xHCl. form: amorphous powder. Quality Level: 100. reaction suitability: reactivity: carboxyl reactive, reagent type: ligand-linker conjugate. functional group: amine. storage temp.: 2-8°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.Shipping Information:
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- UPC:
- 41116012
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 925039-50MG
- Temperature Control Device:
- Yes
