General description
Ebselen is a sympathomimetic amine.
Application
Ebselen has been used as a:
- voltage-dependent calcium channels (VDCCs) blocker
- glutathione peroxidase mimetic to test its inhibitory effect on contraction-mediated deoxy glucose (2-DG) uptake in mouse
extensor digitorum longus (fast-twitch) muscle
- glucocerebrosidase inhibitor
- hepatitis C virus helicase inhibitor
Biochem/physiol Actions
An organo-selenium compound possessing antioxidant properties. Inhibits mammalian lipoxygenases in the absence of thiol groups, and glutathione S-transferase and papain via the interaction with cysteine residues. Also inhibits indoleamine 2,3-dioxygenase by covalently modifying a cysteine residue, the effect being reversible with dithiothreitol. Inhibits oxidation of low density lipoproteins (LDL).
Ebselen, a glutathione-peroxidase-mimic, elicits anti-inflammatory activity. It also has anti-atherosclerotic functionality. Ebselen displays antibacterial action on) multidrug-resistant Staphylococcus aureus (MRSA) infections and could be a potential therapeutic target for treating MRSA based skin infection. It is regarded as neuroprotective agent and elicits chemopreventive functionality in inflammation-associated carcinogenesis.
Shipping Information:
Hazmat Fee: $65.00 + applicable shipping charges are added after the order is placed.
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- UPC:
- 12352200
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- Yes
- MPN:
- E3520-100MG
- CAS:
- 60940-34-3
