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eif4a3-in-2 (c09-1130-968)

eIF4A3-IN-2 (C09-1130-968)

Aladdin

Catalog No.
C09-1130-968
Manufacturer No.
E650418-50mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA
Price: $3,058.73
List Price: $3,398.59

eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC 50 of 110 nMIn VitroeIF4A3-IN-2 (compound 2) binds to the allosteric region in eIF4A3 and inhibits in vitro ATPase, helicase, and

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eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC 50 of 110 nMIn VitroeIF4A3-IN-2 (compound 2) binds to the allosteric region in eIF4A3 and inhibits in vitro ATPase, helicase, and cellular nonsense-mediated RNA decay (NMD) activities. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: HEK293T cells (transfected with the NMD reporter) luciferase assay Concentration: 0.3, 1, 3, or 10 μM Incubation Time: 3 or 6 h Result: eIF4A3-IN-2 induces an approximately 3.2-fold increase in luciferase activity, indicating that NMD is inhibited by compound 2.Form:SolidIC50& Target:IC50: 110 nM (eIF4A3). Specification: 0.99 Molecular Formula: C25H19Br2ClN4O2 Molecular Weight: 602.7 PubChem CID: 131953885 Isomeric SMILES: C1CN([C@H](CN1C(=O)C2=C3C=CC(=CN3N=C2)Br)C4=CC=C(C=C4)Cl)C(=O)C5=CC=C(C=C5)Br
UPC:
12352005
Condition:
New
Availability:
8-12 weeks
Weight:
1.06 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
E650418-50mg
CAS:
2095677-20-4
Product Size:
50mg


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