General description
A potent inhibitor of human leukocyte elastase (HLE) (Ki = 10 µM).
A potent irreversible inhibitor of human leukocyte elastase (HLE)(Ki = 10 µM). Protects against lung injury induced by instillation of elastase.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Human leukocyte elastase (HLE)
Product does not compete with ATP.
Reversible: no
Target Ki: 10 µM against human leukocyte elastase (HLE)
Warning
Toxicity: Standard Handling (A)
Sequence
MeOSuc-Ala-Ala-Pro-Val-CMK
Reconstitution
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Fletcher, D.S., et al. 1990. Am. Rev. Respir. Dis.141, 672.
Stein, R.L., and Trainor, D.A. 1986. Biochemistry 25, 5414.
Powers, J.C., et al. 1977. Biochim. Biophys. Acta 485, 15.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 502.99. Empirical Formula: C22H35ClN4O7. Quality Level: 100. Assay: ≥. 97% (HPLC). form: solid. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, desiccated. color: white. solubility: DMSO: 10 . mg/mL, methanol: soluble. shipped in: ambient. storage temp.: −. 20°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 51282525
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 324745-5MG