Elimusertib hydrochloride (C09-1131-369)

Elimusertib (BAY 1895344) hydrochloride is a potent, orally active and selective ATR inhibitor with an IC 50 of 7 nM. Elimusertib hydrochloride has anti-tumor activity . Elimusertib hydrochloride can be used for the research of solid tumors and lyIC50& Target:ATR 7 nM (IC 50 )In Vitro:Elimusertib hydrochloride potently inhibits the proliferation of a broad spectrum of human tumor cell lines with a median IC 50 of 78 nM. Elimusertib hydrochloride potently suppresses hydroxyurea-induced H2AX phosphorylation (IC 50 : 36 nM) . EliIn Vivo:Elimusertib hydrochloride shows potent anti-tumor efficacy in monotherapy in a variety of xenograft models of ovarian and colorectal cancer, and causes complete tumor remission in mantle cell lymphoma models. Elimusertib hydrochloride (50 mg/kg; p.o.Biological Activity:Elimusertib (BAY 1895344) hydrochloride is a potent, orally active and selective ATR inhibitor with an IC 50 of 7 nM. Elimusertib hydrochloride has anti-tumor activity. Elimusertib hydrochloride can be used for the research of solid tumors and ly. Specifications and Purity: 10mM in DMSO. Molecular Formula: C20H22ClN7O. Molecular Weight: 411.89.