Emedastine (C007B-154680)

InformationEmedastine is a potent, high affinityhistamine H1-receptor-selectiveantagonist with Ki of 1.3 ±0.1 nM for H1-receptors while considerably weaker at H2- (K1 = 49,067 ± 11,113 nM) and H3-receptors (Ki = 12,430 ± 1,282 nM).TargetsH1 receptor (Cell-free assay) 1.3 nM(Ki)In vitroEmedastine is capable of potently inhibiting histamine-induced cytokine release as well as the chemotaxis of eosinophils, thereby influencing factors contributing to the inhibition of the signs and symptoms of allergic diseases.In vivoIn human, the half-life of emedastine, when administered as slow release capsules is of about 6±7 h. Specification: 0.97 Molecular Formula: C17H26N4O Molecular Weight: 302.41 PubChem CID: 3219 Isomeric SMILES: CCOCCN1C2=CC=CC=C2N=C1N3CCCN(CC3)C Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/E413308-SCI_90ec5718433717236ac4881a8d0db889.pdf