EN450 (C005B-308770)

Catalog No.: C005B-308770
Mfr. No.: SML3567-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 1
UOM: EA

Price: $767.15

List Price: $852.39

Biochem/physiol Actions EN450 is a molecular glue degraders of the oncogenic transcription factor NFKB1 that induces ternary complex formation between ubiquitin-conjugating enzyme E2D1 (UBE2D1) and NFKB1. EN450 covalently modifies an allosteric

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Biochem/physiol Actions

EN450 is a molecular glue degraders of the oncogenic transcription factor NFKB1 that induces ternary complex formation between ubiquitin-conjugating enzyme E2D1 (UBE2D1) and NFKB1. EN450 covalently modifies an allosteric C111 in UBE2D1 and significantly reduces NFKB1 p105 levels. It impairs leukemia cell viability in a NEDDylation and proteasome-dependent manner at 50 µM.

UPC:: 12352200
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3567-25MG
CAS:: 793719-01-4

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