ENA-78 (8-78) HUMAN

General description

ENA-78 (epithelial cell-derived neutrophil activating peptide-78) is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. ENA-78 is a chemoattractant for neutrophils. The murine homolog of ENA-78 is called LIX. Three N-terminal truncated variants of human ENA-78; ENA 5-78, ENA 8-78, ENA 9-78, contain 74, 71, and 70 amino acid residues, respectively, possess increased biological activity. ENA-78 contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR′ motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Recombinant human ENA-78 is a 7.8 kDa protein consisting of 71 amino acid residues. The ENA-78 gene is mapped to human chromosome 4q13.3.

Biochem/physiol Actions

ENA-78 (epithelial cell-derived neutrophil activating peptide-78) gene expression is associated with sepsis, atherosclerosis, COPD (chronic obstructive pulmonary disease), psoriasis and gastrointestinal inflammation. ENA-78 is angiogenic factor and is associated with cancer progression. Upregulation of ENA-78 gene is observed in non‐small‐cell lung cancer, head, neck, gastric, pancreatic, colorectal, prostate and lung cancer squamous cell carcinoma.

ENA-78 is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. Recombinant human ENA-78 is a 7.8 kDa protein consisting of 71 amino acid residues.

Sequence

LRELRCVCLQ TTQGVHPKMI SNLQVFAIGP QCSKVEVVAS LKNGKEICLD PEAPFLKKVI QKILDGGNKE N

Physical form

Lyophilized with no additives.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

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